Systems Chemical Biology of Infection and Resistance

We study how pathogenic bacteria survive and infect, using the chemical biology toolbox to define bacterial gene functions and explore networks of gene-gene functional interdependencies.

We apply this systems chemical biology approach to understand infection and resistance: the resilience of bacterial pathogens during infection processes and their genetic flexibility to escape antibiotic challenge.

Join our team!

Over the next several months, we will be recruiting students and postdocs to advance projects focusing on the molecular, systems, and chemical biology of bacterial pathogens.

The excitement of scientific inquiry and the opportunities of scientific training should be accessible to and include people with diverse backgrounds, experiences, and aspirations. We strongly encourage applications from members of groups which are under-represented in science.

Graduate students

PhD students are recruited through the Crick Institute’s central PhD program which opens for applications in Autumn each year.


We have open position here, focusing on integrating data science and AI with wet lab work, with an application to mechanism of action of bioactive small molecules in M. tuberculosis. Please upload your CV and a cover letter briefly summarising your scientific background and goals.

We’re particularly interested in recruiting computational biologists interested in incorporating bench work, or microbiologists and chemical biologists who want to adopt quantitative and computational approaches.

We expect to advertise a postdoc position on the chemical genetics of nitrogen metabolism in M. tuberculosis very soon, to start on 1 September 2021. Please email Eachan if you might be interested.